Clinico-Pathological Cases: Summaries of Papers
ثبت نشده
چکیده
We report an original case of eosinophilic panniculitis secondary to injection of zinc-containing insulin. Eosinophilic panniculitis is seen in association with a wide variety of clinical conditions including arthropod bite, infection, leucocytoclastic vasculitis, malignancy and injection granuloma. A 65-year-old woman with insulin-dependent diabetes presented with a 1-year history of a plaque on her right thigh and a shorter history of three smaller plaques on the left thigh. She only ever injected insulin into her thighs. She had thought the lesions to be abscesses but had been surprised at the absence of pus at any time. Despite repeated courses of antibiotics and dressings they had failed to heal, prompting referral. Examination of the right thigh revealed a 10 · 4 cm indurated purplish plaque. The centre was atrophic and on palpation a significant tissue defect was detectable. The left thigh lesions were 3 cm diameter erythematous indurated plaques. All lesions were tender. Two biopsies were obtained. The first biopsy showed areas of granulomatous inflammation in the deep dermis but was too superficial to assess the fat. The second biopsy showed a predominantly septal panniculitis with a florid eosinophilic infiltrate. Eosinophilic panniculitis has been reported in association with injection granuloma. Zinc-containing insulin has been shown to cause injection granulomas (Jordaan HF, Sandler M. Zinc-induced granuloma – a unique complication of insulin therapy. Clin Exp Dermatol 1989; 14: 227–9). Our patient was injecting human actrapid insulin (NovoNordisk) which contains zinc chloride. This is the first reported case of eosinophilic pannicultis secondary to injection of zinccontaining insulin. We propose that the zinc component of the insulin has been the trigger for our patient’s lesions.
منابع مشابه
Evaluation of clinical versus pathological difference in 232 cases with oral lesion
Background: The clinical and pathological evaluation of oral lesions are very important in this field. The purpose of this study was to assess clinico- pathological agreement on 232 cases with oral lesion s.Methods: The consecutive files of 232 patients with oral lesions from pathological laboratory archives of Babol Dental faculty and Shahid Beheshti Hospital were reviewed and the data include...
متن کاملClinico-Pathological Study of Cutaneous Granulomatous Lesions- a 5 yr Experience in a Tertiary Care Hospital in India
Background: Granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. Histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. The aims of the present study were clinico-pathological evaluation of granulomatous skin l...
متن کاملEvaluation of Clinico-Radio-Pathological Features of Tubular Adenoma of Breast: a Study of Ten Cases with Histopathological Differential Diagnosis
Background & Objectives: Tubular adenomas are rare benign epithelial tumours of breast affecting predominantly females of child bearing age group. Till now, very small number of cases have been reported in the literature. Present study was carried out to evaluate the clinico-pathological features of tubular adenoma cases diagnosed during three years study period along with discussion of possibl...
متن کاملTheileriosis in Pure and Crossbred Friesian Cattle in Khartoum State, Sudan: Clinico-Pathological Observations
متن کامل
Evaluation of Clinico Ultra-Sonography and Pathological Findings of Ovarian Masses in Patients referred to Kosar Hospital, Qazvin
Introduction: Today, despite many optimal imaging methods for evaluation of ovarian mass, the survival rate of patient was not significantly changed. Object of present study was evaluation of Clinico Ultra- Sonography and pathological findings of ovarian masses in patients referred to Kosar Hospital. Methods: In this analytic study, information of clinico Ultra-Sonography and pathological findi...
متن کامل